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ECTRIMS 2023 | Associations between paramagnetic rim lesions and proteomic levels

Jack Reeves, MD, University at Buffalo, The State University of New York, New York, NY, delves into a study examining the association between paramagnetic rim lesions (PRLs) and serum proteomic levels in multiple sclerosis (MS) patients. Previous research indicated a link between PRLs and serum neurofilament light, a marker of axonal degeneration, suggesting PRLs are tied to increased brain tissue destruction. This study aimed to verify these findings using a dataset of 141 individuals with baseline MRIs and serum proteomic measurements. Surprisingly, the study did not replicate the earlier results. A potential reason for the disparity might be the older age and extended disease duration of this study’s cohort. The findings prompt further inquiry into when and under which conditions these associations between molecular and imaging markers are present in MS, potentially uncovering varying dynamics across different disease stages. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.

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