Jack Reeves, MD, University at Buffalo, The State University of New York, New York, NY, discusses the relationship between paramagnetic rim lesions (PRLs) and disease severity in multiple sclerosis (MS) patients. Previous research indicated that PRLs were linked with increased disability and brain atrophy. A recent study aimed to assess the correlation between PRLs and longer-term relapse rates, building upon earlier work that had shown PRL associations over shorter durations. Results revealed that the presence of one or more PRLs at baseline predicted higher relapse rates over a decade. Especially those with clinically isolated syndrome or relapsing-remitting MS showed a risk over four times greater for relapses. This understanding may help in the clinical decision-making process, especially when selecting disease-modifying therapies (DMTs) that carry potential side effects. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.
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