ACTRIMS 2024 | Factors influencing the appearance and disappearance of paramagnetic rim lesions in people with MS

Paramagnetic rim lesions (PRLs) serve as potential markers of chronic inflammation in multiple sclerosis (MS), attracting attention for studying novel treatment strategies. Jack Reeves, MD, The State University of New York, New York, NY, discusses his study tracking PRL evolution in 152 patients with MS over 8 years. The research highlights a low overall incidence of new PRLs (18%), with their presence influenced by baseline gadolinium enhancing lesion volume and the use of disease-modifying therapies (DMTs). DMT users were significantly less likely to develop new PRLs compared to patients not on DMTs, particularly those on high-efficacy agents. However, DMT use did not influence PRL disappearance. Dr Reeves expresses interest in exploring additional factors impacting PRL presence and their long-term impact. This interview took place during the annual ACTRIMS Forum 2024.

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