AAN 2024 | Evidence for metabolic dysfunction in migraine

Elizabeth Leroux, MD, FRCP, University of Calgary, Calgary, Canada, comments on emerging evidence on abnormal energy metabolism in migraine. Although many questions remain to be answered in this space, Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. Notably, people with mitochondrial disorders are known to have a higher risk of migraine, suggesting that mitochondrial dysfunction may be one of the triggers for the development of migraine. Dr Leroux uses obesity as an example, highlighting the mechanisms by which this metabolic condition may play a role in migraine. This interview took place at the American Academy of Neurology (AAN) Annual Meeting 2024 in Denver, CO.

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