EAN 2023 | Contribution of genetics to our understanding of migraine

Irene de Boer, MD, from Leiden University Medical Center, Leiden, Netherlands, talks about the contributions of genome-wide association studies (GWAS) to our understanding of the genetic origins of migraines, and how these studies can help us to develop treatments in the future. Recent increases in the number of patients involved in GWAS has led to an increase in the number of single nucleotide polymorphisms (SNP) found and associated with different kinds of migraine. These SNPs provide information about the genetic origins of migraines and indicate neurons and vasculature as potential therapeutic targets. Different types of migraine can be compared using GWAS, for example migraines with and without aura have shown several SNPs associated specifically with each type of migraine and some SNPs associated with both. By determining which proteins and pathways are associated with these SNPs, the hope is that targeted therapeutics may be developed in the future. Recorded at the 9th Congress of the European Academy of Neurology (EAN) 2023 held in Budapest, Hungary.

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