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WSC 2023 | Blood flow arrest during EVT to improve reperfusion as stroke treatment

Permesh Singh Dhillon, MBBS, FRCR, Nottingham University Hospitals NHS Trust, Nottingham, UK, discusses the Phase II ProFATE trial (NCT05020795). This study investigated the use of balloon guide catheters (BGC) to induce transient proximal blood flow arrest during endovascular thrombectomy (EVT) as a treatment for acute ischemic stroke. It aimed to assess whether blood flow arrest could facilitate smoother clot retrieval, ultimately enhancing reperfusion and functional recovery. Between October 2021 and June 2023, 124 patients were randomized into two groups: one receiving BGC during EVT and the other not. The primary outcome measure was a 25% improvement in near-complete/complete reperfusion in the BGC arm, but this was not achieved. Some secondary outcomes did show results in favor of BGC use, highlighting the potential for further exploration in future trials. This interview took place at the World Stroke Congress (WSC) 2023 in Toronto, Canada.

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