ESOC 2026 | Aims of the OPTIMAL-STROKE trial: defining blood pressure targets after ischemic stroke
Gisele Sampaio Silva, MD, PhD, Federal University of São Paulo, São Paulo, Brazil, discusses the OPTIMAL-STROKE trial (NCT04036409), which is evaluating blood pressure levels after ischemic stroke in over 4,000 randomized patients. Dr Silva highlights that the trial aims to determine if two different blood pressure levels can prevent major cardiovascular events in the long term, with results expected in the second semester of 2026. This interview took place at the 12th European Stroke Organisation Conference (ESOC) in Maastricht, The Netherlands.
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Transcript
Yeah, so we are really proud to present here the baseline data of the Optimal Stroke. The Optimal Stroke is the biggest trial that is evaluating blood pressure levels after a specifically ischemic stroke. So it comes after the important results of the TRIDENT trial, but focuses on the ischemic stroke population, so we actually had randomized more than 4,000 patients to two different levels of blood pressure, and we are following these patients, and results should be ready probably in the second semester of 2026...
Yeah, so we are really proud to present here the baseline data of the Optimal Stroke. The Optimal Stroke is the biggest trial that is evaluating blood pressure levels after a specifically ischemic stroke. So it comes after the important results of the TRIDENT trial, but focuses on the ischemic stroke population, so we actually had randomized more than 4,000 patients to two different levels of blood pressure, and we are following these patients, and results should be ready probably in the second semester of 2026. So here we present the baseline data of the patients; they are patients that are very sick, they have comorbidities, and the idea is to follow them up with these two different blood pressure levels to check if it will avoid major cardiovascular events on a long-term basis.
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