Christos Lisgaras, PhD, The Nathan S. Kline Institute for Psychiatric Research, NYU Langone Health, New York, NY, shares an overview of his recent work investigating the occurrence of high-frequency oscillations (HFOs) in animal models of Alzheimer’s disease (AD) and epilepsy. HFOs (250-500Hz) are well documented in epilepsy, implicated in seizure onset. In this study, experiments conducted in three different mouse models of AD demonstrated the occurrence of hippocampal and cortical HFOs during slow wave sleep. HFOs were detectable as early as 1 month of age, before the onset of robust neuropathology, suggesting this signal may be an early marker of AD. Additionally, the HFOs that occurred in AD mouse models were indistinguishable from those seen in intra-hippocampal kainic acid and pilocarpine models of epilepsy. These results describe for the first time that HFOs occur in AD mouse models and thus, are not unique to epilepsy. Dr Lisgaras comments on the potential implications of these data in our understanding of the overlap between AD and epilepsy. This interview took place during the American Epilepsy Society (AES) 2023 Annual Meeting congress in Orlando, FL.
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