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AES 2023 | High frequency oscillations versus interictal spikes in Alzheimer’s disease models

New findings from Christos Lisgaras, PhD, The Nathan S. Kline Institute for Psychiatric Research, NYU Langone Health, New York, NY, and his team have demonstrated the occurrence of high frequency oscillations (HFOs) in animal models of Alzheimer’s disease (AD), implicating these signals as a potential EEG biomarker in AD. Interictal spikes (IIS) are also well documented in Alzheimer’s disease, but it is unknown how they compare to HFOs. In this interview, Dr Lisgaras, discusses his work looking at HFOs and IIS in three different AD mouse models. Overall, HFOs were more frequent than IIS and occurred in more behavioral states, indicating that they may be a better biomarker for AD. Additionally, higher HFO rates correlated with fewer IIS, suggesting they may have a competing relationship. This interview took place during the American Epilepsy Society (AES) 2023 Annual Meeting congress in Orlando, FL.

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