ISC 2024 | Reperfusion outcomes in patients with pre-stroke dementia

Aravind Ganesh, Cumming School of Medicine at the University of Calgary, discusses a systematic review and meta-analysis focused on thrombolysis and thrombectomy in patients with pre-stroke dementia or cognitive impairment. The analysis included five observational studies with over a thousand dementia patients and nearly 3000 without dementia. For thrombolysis, no significant differences were observed in favorable outcomes, mortality, or intracerebral hemorrhage rates between the two groups. In the limited data on thrombectomy, no significant differences were noted in outcomes, except for an increased odds of intracerebral hemorrhage in dementia patients. The findings suggest that reperfusion therapies appear safe for patients with dementia, but efficacy remains uncertain, necessitating more rigorous studies considering nuanced outcome interpretations. This interview occurred during the International Stroke Conference 2024 in Phoenix, AZ.

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