The use of cannabinoids for the treatment of epilepsy has become a hot topic in recent years, with increasing medical and public interest in their potential benefits. Andreas Schulze-Bonhage, PhD, University Medical Center Freiburg, Freiburg im Breisgau, Germany, highlights some of the major questions surrounding their use and key knowledge gaps that need tackling in years to come. One such need is an improved understanding of the differences between varying compounds. Research into how compounds differ in safety, efficacy, and mechanism of action is needed. This interview took place during the European Academy of Neurology 2021 congress.