ISC 2025 | Intra-arterial thrombolytics after endovascular thrombectomy in acute ischemic stroke
Aristeidis Katsanos, MD, McMaster University, Hamilton, Ontario, Canada, highlights the promising efficacy of intra-arterial thrombolytics after endovascular thrombectomy for the treatment of acute ischemic stroke. Dr Katsanos notes that evidence from multiple trials suggests that intra-arterial alteplase or tenecteplase after endovascular thrombectomy can lead to improved patient outcomes, and he anticipates that this approach will soon change clinical practice. This interview took place at the 2025 International Stroke Conference (ISC), held in Los Angeles, CA.
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Transcript
Yeah, so ISC was great this year. I mean, it’s not only that you have the chance to meet colleagues and have an in-person meeting and catch up with research, But I think one very important research topic that was investigated and presented during the ISC is the use of intra-arterial thrombolytics after endovascular thrombectomy. So there were independent trials showing that this approach seems to be effective, but more importantly, it seems to be efficacious and improve patient outcomes...
Yeah, so ISC was great this year. I mean, it’s not only that you have the chance to meet colleagues and have an in-person meeting and catch up with research, But I think one very important research topic that was investigated and presented during the ISC is the use of intra-arterial thrombolytics after endovascular thrombectomy. So there were independent trials showing that this approach seems to be effective, but more importantly, it seems to be efficacious and improve patient outcomes. So, in fact, we have evidence now from more than two trials that intra-arterial alteplase or tenecteplase after endovascular thrombectomy can improve patient outcomes. Again, those trials, most of the trials have not been published yet, so we’re waiting for the publications, but I think it’s a game changer and it’s going to penetrate and change clinical practice in the very near future.
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