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SLEEP 2026 | What are the cardiovascular effects of a single dose of Adderall?

Bhanu Prakash Kolla, MD, MRCPsych, Mayo Clinic, Rochester, MN, discusses insights from a recent publication examining the cardiovascular effects of a single dose of Adderall in healthy young adults. He highlights transient increases in heart rate and blood pressure and explains why these findings are relevant for understanding the risks associated with stimulant misuse, particularly in individuals with underlying cardiovascular vulnerabilities. This interview took place at the 40th annual meeting of the Associated Professional Sleep Societies (APSS) in Baltimore, MD.

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Transcript

So this was actually an editorial we were writing on a randomized controlled trial where they took healthy subjects, young subjects, gave them a single dose of Adderall or a placebo, and looked at what happened to heart rate and blood pressure. And what they showed was that after a single dose, there was an increase in heart rate, there was an increase in blood pressure too, and that was relatively transient...

So this was actually an editorial we were writing on a randomized controlled trial where they took healthy subjects, young subjects, gave them a single dose of Adderall or a placebo, and looked at what happened to heart rate and blood pressure. And what they showed was that after a single dose, there was an increase in heart rate, there was an increase in blood pressure too, and that was relatively transient. So we have for a long time known that people who misuse stimulants have higher rates of cardiovascular events. We did not completely understand how high that risk would be and what the possible mechanisms could be. So this study shed some light on those potential mechanisms, and in our editorial, we were commenting on those findings, but also using those findings as a public health measure to warn people, especially those who are at high risk or have aneurysms or other reasons why misusing stimulants or Adderall could put them at risk.

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