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ECTRIMS 2023 | Assessing predictors of relapse in MOGAD patients

Torge Rempe, MD, PhD, University of Florida College of Medicine, Gainesville, FL, discusses a multicenter, retrospective study aimed at evaluating predictors for relapse in patients with myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD). The research examined 541 charts, culminating in a cohort of 76 patients. Key findings revealed that approximately two-thirds relapsed, with 19% experiencing their first relapse five years after the initial episode. Potential predictors included pediatric onset, Hispanic ethnicity, clinical syndrome of meningoencephalitis, high pleocytosis, and elevated anti-MOG titers. The study also explored disease-modifying therapies, noting IVIg as a promising maintenance therapy. However, the retrospective design presented limitations, including heterogeneous data and potentially inadequate follow-up periods. Further research is imperative to validate the identified predictors. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.

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