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WSC 2022 | Impact of brain frailty on thrombectomy outcomes after acute ischemic stroke

Faysal Benali, MD, PhD Candidate, Maastricht University Medical Center, Maastricht, The Netherlands, shares an overview of his work looking at the association between brain frailty and functional outcome after endovascular thrombectomy (EVT). Measures such as white matter disease burden and brain atrophy are important surrogates of brain frailty and may therefore determine clinical outcomes after EVT. Over 1000 patients from the ESCAPE-NA1 trial with CT data were retrospectively analyzed. Periventricular and deep white matter disease burden was scored with the Fazekas scale and the impact of these scores on mRS measures at day 5, 30, and 90 was assessed. It was shown that mRS outcomes differed by white matter disease at all timepoints, with patients showing higher burden scores having worse outcomes. Similarly, cortical and subcortical brain atrophy were also associated with less favorable outcomes over time. This interview took place at the World Stroke Congress 2022 in Singapore.

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