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AAN 2023 | Association of B-cell subsets and AQP4 antibody titers with disease activity in NMOSD

Friedemann Paul, MD, Charité-Universitätsmedizin Berlin, Berlin, Germany, discusses a study that evaluated the relationship between peripheral blood B-cell subsets and aquaporin-4 (AQP4) immunoglobulin G (IgG) titers and NMOSD attacks in participants of N-MOmentum (NCT02200770). Proinflammatory CD19+ B cells are considered a key driver of NMOSD attacks; however, less is known about the association of attacks with various B-cell subsets. Increased levels of B-cell subsets at the time of attack were observed in the placebo but not inebilizumab group, particularly in the plasma cells subset. Additionally, inebilizumab treatment was associated with reduction in AQP4-IgG in a subset of patients. This interview took place at the American Academy of Neurology Annual Meeting 2023 in Boston, MA.

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Grants or contracts: German Ministry for Education and Research (BMBF), Deutsche Forschungsgemeinschaft (DFG), Einstein Foundation, Guthy Jackson Charitable Foundation, EU FP7 Framework Program, Biogen, Genzyme, Merck Serono, Novartis, Bayer, Roche, Parexel and Almirall.
Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: Guthy Jackson Foundation, Bayer, Biogen, Merck Serono, Sanofi Genzyme, Novartis, Alexion, Viela Bio, Roche, UCB, Mitsubishi Tanabe and Celgene.
Participation on a Data Safety Monitoring Board or Advisory Board: Celgene, Roche, UCB, Merck.
Leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid: Academic Editor PLos One, Associate Editor von Neurology® Neuroimmunology & Neuroinflammation.