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AAN 2023 | Inebilizumab in AQP4+ NMOSD patients with history of immunosuppression treatment: N-MOmentum study

Friedemann Paul, MD, Charité-Universitätsmedizin Berlin, Berlin, Germany, describes the findings from an analysis evaluating long-term outcomes of inebilizumab treatment in AQP4+ NMOSD participants from the N-MOmentum trial (NCT02200770) with a history of immunosuppressant therapy as compared to those without. N-Momentum was a 28-week-randomized Phase II/III trial of inebilizumab vs. placebo, with an optional open-label extension. In the analysis, AQP4+ participants who received inebilizumab were grouped by no history of immunosuppression therapy beyond the treatment of acute NMOSD attacks (naïve) or prior azathioprine (AZA) and/or mycophenolate mofetil (MMF) therapy. Results showed that AQP4+ NMOSD participants treated with prior AZA/MMF therapy demonstrated a similar efficacy and safety profile as participants without prior immunosuppressant therapy. This interview took place at the American Academy of Neurology Annual Meeting 2023 in Boston, MA.

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Grants or contracts: German Ministry for Education and Research (BMBF), Deutsche Forschungsgemeinschaft (DFG), Einstein Foundation, Guthy Jackson Charitable Foundation, EU FP7 Framework Program, Biogen, Genzyme, Merck Serono, Novartis, Bayer, Roche, Parexel and Almirall.
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