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AAN 2024 | The HEALEY ALS Platform Trial: a multi-agent evaluation

Jinsy Andrews, MD, FAAN, Columbia University, New York, NY, discusses ongoing investigations in the innovative HEALEY ALS Platform Trial (NCT04297683), which is evaluating therapies for amyotrophic lateral sclerosis (ALS). This trial uses an adaptive platform to test multiple investigational products that may be candidates for confirmatory Phase III trials. Since 2020, five therapies have been evaluated, with two of them showing preliminary activity that warrants further investigation. This interview took place at the American Academy of Neurology (AAN) Annual Meeting 2024 in Denver, CO.

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Transcript

There’s plenty of ongoing clinical trials, I think there’s almost over 50 clinical development programs currently ongoing globally for amyotrophic lateral sclerosis (ALS). That means that we have to get through these pretty quickly. One of the highlights from the presentation that I’ll be giving is talking about being innovative in clinical trials. One is the HEALEY ALS Platform Trial: where we try to test multiple therapies in an infrastructure that’s already set up so that we can quickly evaluate a therapy and see if it can be graduated to a confirmatory Phase III...

There’s plenty of ongoing clinical trials, I think there’s almost over 50 clinical development programs currently ongoing globally for amyotrophic lateral sclerosis (ALS). That means that we have to get through these pretty quickly. One of the highlights from the presentation that I’ll be giving is talking about being innovative in clinical trials. One is the HEALEY ALS Platform Trial: where we try to test multiple therapies in an infrastructure that’s already set up so that we can quickly evaluate a therapy and see if it can be graduated to a confirmatory Phase III. Since 2020, five therapies have been evaluated. Within those, two of them have shown some preliminary signals that warrant further investigation. There are two ongoing, two additional (the sixth and seventh investigational product), which are actually ongoing in the HEALEY Platform Trial. We’ll await results later this year.

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