Augusto Miravalle, MD, FAAN, University of Colorado School of Medicine, Aurora, CO, shares insights into the promise of precision medicine in multiple sclerosis (MS) and factors to consider when making treatment decisions. It is important to consider patient-related factors, such as race, ethnicity, and preferences, to optimize the patient experience of shared decision-making Treatment-related factors that should be considered when choosing therapies for patients include the mechanisms of action of the drug and perceived efficacy. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.