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AAN 2023 | Chronic inflammation in MS

Augusto A. Miravalle, MD, FAAN, University of Colorado School of Medicine, Aurora, CO, discusses the concept of chronic inflammation in multiple sclerosis (MS) and its relationship to relapse activity. The presence of B- and T-cell clusters in the intermeningeal spaces of MS patients, which were previously thought to only occur in secondary progressive MS, but now studies have shown that they also occur earlier in the disease process. These clusters, known as tertiary lymphoid structures, are believed to contribute to chronic inflammation in the central nervous system. Additionally, activated microglial cells in the periphery of chronic lesions also play a role in perpetuating inflammation and can be visualized on MRI scans as paramagnetic rim lesions. This interview took place at the American Academy of Neurology Annual Meeting 2023 in Boston, MA.

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Dr Miravalle received consulting honoraria, speaker honoraria and/or research funding from: Alexion, EMD Serono, Genentech, BMS, Horizon, Novartis, Biogen, MF Foundation, MSAA, CanDo MS, American Academy of Neurology.