EAN 2026 | The potential value of broad rim lesions in the understanding and management of multiple sclerosis
Joost Smolders, MD, PhD, Erasmus University Medical Center, Rotterdam, Netherlands, discusses the potential value of broad rim lesions in the understanding and management of multiple sclerosis. Dr Smolders highlights that these lesions could help to stratify patients for trials and inform treatment decisions. This interview took place at the 12th Congress of the European Academy of Neurology (EAN) in Geneva, Switzerland.
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Transcript
Well, I think the past years the field really discovered a lot of things that helped to explain the heterogeneity in people with multiple sclerosis. For instance, if you look at MRI data, you know, we used to look at the presence of T2 hyper-intense lesions and now we look with a far more granular view at these MRI images. And if we look at white matter lesions, we can now identify paramagnetic rim lesions...
Well, I think the past years the field really discovered a lot of things that helped to explain the heterogeneity in people with multiple sclerosis. For instance, if you look at MRI data, you know, we used to look at the presence of T2 hyper-intense lesions and now we look with a far more granular view at these MRI images. And if we look at white matter lesions, we can now identify paramagnetic rim lesions. We can identify slowly expanding lesions. And I think, you know, if we can image correlates of broad rim lesions also on MR imaging, this could further improve our understanding of what progression in MS is and how you can capture this with regular imaging strategies in our patients. So it can really help to stratify our patients for trials, for maybe also therapies targeting progression in the future. I think there’s a lot we can learn from it.
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