EAN 2025 | Soluble factors contribute to broad rim lesion-formation in multiple sclerosis
Joost Smolders, MD, PhD, Netherlands Institute for Neuroscience, Amsterdam, Netherlands, comments on a study investigating soluble factors that contribute to broad rim lesion-formation in multiple sclerosis (MS). Dr Smolders suggests that these lesions are broader than usual due to the presence of soluble factors produced by lymphocytes in the intrathecal compartment. This interview took place at the 11th Congress of the European Academy of Neurology (EAN 2025) in Helsinki, Finland.
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Transcript
Recently we identified broad rim lesions as a biomarker for progressive disease, a severe disease cause of MS. And with our follow-up work we really tried to understand what makes a broad rim lesion a broad rim lesion. Why are these lesions broader than we regularly see in people with MS. And it appears to be the case that especially lesions, mixed active and active lesions which are adjacent to ventricles containing CSF are broader than lesions which are not adjacent to ventricles and especially also lesions which contain perivascular cuffs, so these aggregates of lymphocytes also are broader than lesions lacking these phenomena...
Recently we identified broad rim lesions as a biomarker for progressive disease, a severe disease cause of MS. And with our follow-up work we really tried to understand what makes a broad rim lesion a broad rim lesion. Why are these lesions broader than we regularly see in people with MS. And it appears to be the case that especially lesions, mixed active and active lesions which are adjacent to ventricles containing CSF are broader than lesions which are not adjacent to ventricles and especially also lesions which contain perivascular cuffs, so these aggregates of lymphocytes also are broader than lesions lacking these phenomena. And we think this really points towards soluble factors being produced by these lymphocytes being produced in this intrathecal compartment which could contribute to the broadness of these lesions. And I think this could offer an important clue to really understand the mechanisms behind this progressive disease as is associated with these broad-rim lesions.
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