ESOC 2026 | Rethinking post-stroke cognitive impairment: more than just isolated deficits or focal lesions

Yeah, so we presented a paper that we’ve recently published in which we took data from three large studies, so in Belgium, in Italy, and in the UK, and they all had the Oxford Cognitive Screen. And so what we did with that data together is we tried to look at behavioural clustering and behavioural profiles. So we put all of the data together, did a latent class analysis, and discovered that we could fit two models quite well, one with five cognitive profiles in it and one more detailed with 13, and so those kind of cognitive profiles we then tried to match to neuroimaging data to see whether lesion symptom mapping and lesion disconnections in terms of the network disconnections could explain some of those profiles. And basically in our results we found that those five profiles and 13 profiles are clearly distinct, they show comorbidities in terms of the kind of co-occurring deficits, and some of them are very much lesion-related. So you could see language deficits after left hemisphere damage. You could see very clearly spatial attentional deficits after right hemisphere damage. But some profiles are also not related to lesions at all. And they were much more related to overall brain health, like atrophy or measures of kind of what we call something like cognitive reserve, so people who’ve had less education tend to do worse in some of these profiles, and you can see that some profiles were clearly characterized by say memory deficits and low education, so they weren’t all mapped to lesions, and that was the main conclusion of the paper.

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