ISC 2026 | Practice-changing trials presented at ISC 2026: OCEANIC-STROKE and CHOICE2
Simona Sacco, MD, University of L’Aquila, L’Aquila, Italy, shares her perspective on practice-changing trial results presented at this year’s ISC that will have the greatest impact in the near future. She highlights the OCEANIC-STROKE (NCT05686070) and CHOICE2 (NCT05797792) trials. This interview took place at the 2026 International Stroke Congress (ISC), held in New Orleans, LA.
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Transcript
So this year exciting trials have been presented at ISC. I think one very important is the OCEANIC-STROKE. It’s a highly expected trial evaluating asundexian against placebo as a secondary prevention measure in patients with non-cardioembolic ischemic stroke. Results will be presented tomorrow. I know those results. And also there was an official anticipation from the company stating that the trial is positive and results are even better than we expected and I think this will be practice-changing and introducing a new agent that can improve the prevention of ischemic stroke...
So this year exciting trials have been presented at ISC. I think one very important is the OCEANIC-STROKE. It’s a highly expected trial evaluating asundexian against placebo as a secondary prevention measure in patients with non-cardioembolic ischemic stroke. Results will be presented tomorrow. I know those results. And also there was an official anticipation from the company stating that the trial is positive and results are even better than we expected and I think this will be practice-changing and introducing a new agent that can improve the prevention of ischemic stroke. One additional trial that was presented just today in the main plenary session is the CHOICE2 trial evaluating intra-arterial alteplase in patients treated with thrombectomy so the setting is acute stroke patients and also this trial was positive with a number needed to treat of seven to improve the functional outcome and so additionally something new and important that can further improve the way we treat the patients with acute ischemic stroke.
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