ISC 2024 | Life’s essential 8 scores and brain health clinical outcomes in middle-aged adults

Santiago Clocchiatti-Tuozzo, MD, Yale School of Medicine, New Haven, CT, discusses research exploring the relationship between cardiovascular risk in middle life and their connection to brain health in later life. The study aimed to understand how the American Heart Association’s Life’s Essential Eight (LE8) scores correlated with key brain health endpoints such as stroke, dementia, and late-life depression. LE8 scores reflect overall cardiovascular health based on the LE8 components: blood pressure, glucose, and cholesterol, body mass index, smoking, physical activity, diet, and sleep duration. Using data from the UK Biobank and the All of Us research program, the study found that poorer LE8 profiles were strongly associated with a higher risk of developing stroke, dementia, or depression over a five-year period. All individuals with a history of these events at baseline were excluded, implying the significance of the impact of cardiovascular health on long-term brain health outcomes. The study contributes valuable insights to the understanding of preventive measures for brain health in connection with cardiovascular well-being. This interview occurred during the International Stroke Conference 2024 in Phoenix, AZ.

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