Seth M. Keller, MD, American Academy of Developmental Medicine and Dentistry (AADMD), discusses epilepsy in adults with intellectual and developmental disabilities (IDDs). This population has a higher prevalence of epilepsy due to the susceptibility of the developing brain. With seizures potentially being more complicated and a high percentage of individuals with IDDs being medically refractory, it is essential that clinicians and neurologists appreciate the complexities presented in this population. Adverse side effects to medication must also be considered; patients with IDDs may not be able to effectively communicate, leading to uncertainties surrounding medication response. Much consideration is required for the complexities surrounding epilepsy in patients with IDDs. This interview took place at the American Academy of Neurology 2022 Congress in Seattle, WA.