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MS at the Limits 2022 | Current understanding of MS genetics and diversity

Benjamin Jacobs, BMBCh. MRCOP, MSc, Queen Mary University of London, London, UK, outlines the current multiple sclerosis (MS) genetics studies with participants of non-European ancestry. There have been some impressive studies looking at South Asian, African, and Hispanic populations, and the broad consensus is that the genetic architecture is similar in people of different ethnic backgrounds. However, the studies have found that there are slightly different genes within each locus and the frequency of these genetic changes varies between different ancestries. These studies have been carried out on a much smaller scale than the European ancestry studies. Therefore, the next step is to carry out larger studies including participants of non-European backgrounds to ensure that these results are the same in larger samples. This interview took place during the 2022 Multiple Sclerosis at the Limits Conference in London, UK.

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