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ESOC 2023 | Predictors of plaque vulnerability and stroke risk in carotid stenosis

Dr. Paul Nederkoorn, MD, PhD, from Amsterdam University Medical Centres, has conducted diagnostic studies, including the Plaque At RISK (PARISK) study, to explore predictors of plaque vulnerability and stroke risk in patients with carotid stenosis. The studies investigated the association between plaque characteristics and the likelihood of recurrent ischemic stroke and transient ischemic attack (TIA). The PARISK study revealed that intraplaque hemorrhage and total plaque volume were strong predictors of an unstable plaque and subsequent recurrent strokes. This suggests that intraplaque hemorrhage and plaque volume can serve as important markers for identifying patients at higher risk of stroke. Dr. Nederkoorn and his team are particularly interested in understanding the surgical risk for patients with intraplaque hemorrhage and carotid stenosis. This information will be obtained through a substudy within the ECST-2 trial, which includes plaque imaging and randomizes patients to surgery versus medical management alone. By analyzing plaque characteristics and their association with stroke risk, Dr. Nederkoorn aims to enhance risk stratification and inform treatment decisions for patients with carotid stenosis. This interview took place during the European Stroke Organisation Conference (ESOC) in Munich, Germany.

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