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Jacek Losy, MD, PhD, Poznań University of Medical Sciences, Poznań, Poland, discusses clinically isolated syndrome (CIS), The first demyelinating clinical episode suggestive of multiple sclerosis (MS). Over time the criteria to describe multiple sclerosis and CIS has changed. It is important to treat CIS as soon as possible to achieve better results and allow patients to continue to be active. This interview took place during the Virtual World Congress on Controversies in Neurology (CONy) 2020.