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AES 2022 | Molecular mechanisms of maladaptive myelination

In a recent study led by Juliet Knowles, MD, PhD, Stanford University, Palo Alto, CA, it was demonstrated that absence seizures resulted in maladaptive myelination that in turn could promote more seizures in animal models of generalized epilepsy. It’s not yet known what molecular mechanisms underlie this process, however during the study, seizure progression was decreased by blocking BDNF-TrkB signaling in the cell population responsible for producing myelin. This suggests that the BDNF-TrkB signaling pathway contributes to maladaptive myelination in some way. Dr Knowles and her team are now looking to use transcriptomic analysis to identify molecular differences between maladaptive myelination and healthy myelination. This interview took place at the American Epilepsy Society (AES) Annual Meeting 2022 in Nashville, TN.

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