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ESOC 2026 | Blood pressure drops during and after thrombectomy linked to poorer stroke outcomes

Christian Nolte, MD, Charité – Universitätsmedizin, Berlin, Germany, discusses findings from a recent analysis examining blood pressure changes within 24 hours after successful mechanical thrombectomy for acute ischemic stroke. Prof. Nolte explains that blood pressure drops, rather than absolute blood pressure levels, were associated with poorer functional outcomes, highlighting the importance of maintaining hemodynamic stability following endovascular therapy. This interview took place at the 12th European Stroke Organisation Conference (ESOC) in Maastricht, The Netherlands.

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Transcript

This actually was a data analysis of a single center where we have very granular data. And the important scientific question is where to have the blood pressure during and especially after endovascular therapy. You may think that you want to have a high blood pressure to ensure perfusion but you may also think that it shouldn’t be too high because the higher blood pressure comes with the risk of intracranial hemorrhage...

This actually was a data analysis of a single center where we have very granular data. And the important scientific question is where to have the blood pressure during and especially after endovascular therapy. You may think that you want to have a high blood pressure to ensure perfusion but you may also think that it shouldn’t be too high because the higher blood pressure comes with the risk of intracranial hemorrhage. So there has been a lot of discussion on where the best blood pressure may be not only in extracranial occlusion of the carotid, but also in all types of large vessel occlusions. And a lot of randomized controlled trials have actually failed to show the optimal blood pressure following EVT. Now we looked at this observational data using a data repository which allowed us to analyze blood pressure at a very high granularity of data points. Not just the initial blood pressure or the last blood pressure, but all the blood pressure measurements in between. Just to show an association with bad outcome. And we could show, which was just nicely published in the Journal of Neurology this year, that it is actually the blood pressure drops that are associated with bad outcome. So rather than high or low blood pressure, it is more, that’s what this data suggests, the dynamics. And we should prevent patients from having blood pressure drops because this goes along with bad outcome.

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Disclosures

Speaker honoraria from AstraZeneca, Bayer and Pfizer.