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BNA 2023 | Glycation of α-synuclein in Parkinson’s disease

Tiago Outeiro, PhD, from the University Medical Center Göttingen, Göttingen, Germany, discusses the connection between diabetes and Parkinson’s disease (PD) at the 2023 Alzheimer’s and Parkinson’s Diseases Conference (AD/PD). He highlights the potential mechanisms connecting these diseases, in particular the glycation of α-synuclein, a major player in the pathogenesis of PD. Prof. Outeiro and his team have been investigating the potential of glycation to cause misfolding and aggregation of α-synuclein. Beyond methylglyoxal, it was found that the glycation with different sugars produces varying results, with some modifications promoting protein oligomerization. Understanding these mechanisms may reveal potential strategies for future therapeutic intervention. This interview took place at The BNA 2023 International Festival of Neuroscience in Brighton, UK.

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