Optic neuritis represents the first manifestation of multiple sclerosis(MS) in 20% to 25% of patients with clinically isolated syndrome and will occur during the disease course in approximately 70% of patients. Giancarlo Comi, MD, Vita-Salute San Raffaele University, Milan, Italy, discusses the inclusion of optic nerve involvement in dissemination in space criteria for MS. The last version of the McDonald diagnostic criteria does not include the optic nerve. However, there is a consensus among experts for the addition of optic nerve lesions to the next McDonald revision. Advances in structural and functional imaging techniques and the new evidence of epidemiological studies seem sufficient to include the optic nerve as the fifth site in the new diagnostic criteria. This interview took place at the 17th World Congress on Controversies in Neurology (CONy) in Dubrovnik, Croatia.
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G. Comi has received consulting and speaking fees from Novartis, Sanofi Genzyme, Genzyme Corporation, Merck KGgA, Merck Serono SpA, Celgene Group, Bristol-Myers Squibb, Janssen, F. Hoffman-La Roche, Almirall SpA