ESOC 2026 | Mechanisms of collateral circulation in AIS due to intracranial large vessel occlusion
Pol Camps-Renom, MD, PhD, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, shares insights into the role of collateral circulation as a key prognostic factor in patients with acute ischemic stroke (AIS) due to intracranial large vessel occlusion. Dr Camps-Renom highlights the association between baseline levels of vascular endothelial growth factor A and collateral status in the acute phase, providing insights into the pathophysiological mechanisms of collateral circulation. This interview took place at the 78th American Academy of Neurology (AAN) Annual Meeting in Chicago, IL.
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Transcript
That was a study performed in a prospective multicentric cohort of patients with a large vessel occlusion in intracranial circulation. They were treated with EVT at some centers in Spain and in this cohort we were very interested in studying collateral circulation. Collateral circulation is a key prognostic factor in patients with a large vessel occlusion and we were interested in describing which baseline factors may be associated with a collateral status in the acute phase...
That was a study performed in a prospective multicentric cohort of patients with a large vessel occlusion in intracranial circulation. They were treated with EVT at some centers in Spain and in this cohort we were very interested in studying collateral circulation. Collateral circulation is a key prognostic factor in patients with a large vessel occlusion and we were interested in describing which baseline factors may be associated with a collateral status in the acute phase. With the final aim of identifying maybe some biomarkers that may guide us in understanding more the pathophysiological mechanism of collateral circulation in the acute phase. And so in this publication we report the results of a first analysis that was that we analyzed baseline levels of vascular endothelial growth factor A which is a plasmatic biomarker that may be related to angiogenesis and to the patency of collateral circulation and we tested the association of these baseline levels of vascular endothelial growth factor and collateral status in this cohort of patients and what we found is that in effect baseline levels of this protein associate independently with the collateral status, giving us insights about plausible pathophysiological mechanisms of collateral circulation status in the acute phase.
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