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Andreas Meyer-Lindenberg, MD, PhD, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany, discusses the impact of the stress experienced by the brain during social isolations, in particular during the coronavirus pandemic, and its effect on mental health. Additionally, Prof. Meyer-Lindenberg outlines strategies to mitigate the adverse effects of social isolation. This interview was recorded during an online conference call with The Video Journal of Neurology (VJNeurology).