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WSC 2023 | Genetic predictors of risk and severity of ICH

Alexander Tsiskaridze, MD, PhD, DSc, FESO, MAE, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, shares current knowledge regarding genetic predictors of risk and severity of intracerebral hemorrhage (ICH). Rapid technological advances and increased data processing capabilities have brought genetics to the forefront in ICH, with large genome-wide association (GWAS) projects identifying novel susceptibility loci. It is now clear that, beyond rare, high-penetrance variants associated with monogenic stroke disorders, that are numerous low-penetrance susceptibility variants that increase the risk of ICH, particularly when their individual impacts are combined. Prof. Tsiskaridze comments on the importance of developing genomic risk scores that could inform personalized prevention. This interview took place at the World Stroke Congress (WSC) 2023 in Toronto, Canada.

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