ECTRIMS 2023 | Sex chromosomes and hormones in neuroinflammation

Rhonda Voskuhl, MD, University of California, Los Angeles, CA, delves into the relationship between sex chromosomes and their potential role in influencing inflammation and neural resilience. Dr Voskuhl highlights the importance of X chromosome genes, particularly given that women possess two X chromosomes while men have one. These genes, in certain instances, escape X-inactivation, leading to dose effects. Such genes can profoundly influence histone methylation and transcriptomics across autosomes. Emerging data suggests that these X chromosome genes may play a pivotal role in modulating inflammation. The complexity intensifies when considering the interaction between these genes and sex hormones throughout different life stages, which collectively may influence both inflammation and neurodegeneration. This interview took place at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Congress 2023 in Milan, Italy.

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