ACTRIMS 2024 | Mapping the functional interactome in MS lesions to shed light on remyelination failure

Milos Opacic, PhD, from Yale University, New Haven, CT, presents research combining single nucleus RNA sequencing (sNuc-Seq) and histological staining to map the functional interactome in MS lesions. This innovative approach enables the spatial and functional characterization of cell interactions. The study highlights a predominance of pro-myelinating interactions, particularly at lesion peripheries, suggesting potential barriers to remyelination in lesion centers. Dr Opacic suggests that myelin inhibitory mechanisms may override pro-myelinating signals, leading to remyelination failure. Downstream signaling analysis implicates serotonin receptor and GPR37 signaling in this process. Future directions include exploring additional lesions and cell types to further unravel the complexities of remyelination failure in MS. This interview took place during the annual ACTRIMS Forum 2024.

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