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WSC 2022 | Patient characteristics by hematoma expansion trajectories

Menglu Ouyang, PhD, MPH, BN, The George Institute for Global Health, University of New South Wales, Sydney, Australia, shares the findings of a post-hoc analysis investigating patient characteristics by hematoma expansion trajectories after intracerebral hemorrhage (ICH). The investigators wanted to look into patient profiles and the effect on blood pressure (BP) lowering on functional outcomes, based on hematoma volume at baseline and 24 hours. Using the Blood pressure in Acute Stroke Collaboration (BASC) dataset, 2450 patients were classified into four groups: stable expansion with favorable outcome, mild expansion with disability, moderate expansion with disability, and large expansion with unfavorable outcome. Patients with large growth were more likely to be younger and to receive surgical intervention than those with mild expansion. Across all groups, baseline hematoma volume was the most important predictor of expansion and functional outcomes. When stratified by baseline volume, hematoma expansion was not associated with functional outcomes in those with moderate-large baseline hematomas. BP-lowering treatment effect on functional outcomes was similar across the four groups. This interview took place at the World Stroke Congress 2022 in Singapore.

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