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EAN 2021 | Horizon scanning in treating disease progression in MS

Nikolaos Grigoriadis, MD, PhD, Aristotle University of Thessaloniki, Thessaloniki, Greece, discusses future strategies to halt disease progression in multiple sclerosis (MS). The optimal approach may involve interfering with microglia and B-cells to control inflammation and, therefore, the neurodegenerative process, using therapeutics such as Bruton’s tyrosine kinase (BTK) inhibitors, which are currently in clinical trials. Early interference with B-cell activity may facilitate macrophage galactose-type lectin (MGL) follicle formation, contributing to demyelination and disease progression. This interview took place during the European Academy of Neurology 2021 congress.