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AAN 2024 | Detecting and preventing secondary brain injury in status epilepticus

Clio Rubinos, MD, from the University of North Carolina at Chapel Hill, Chapel Hill, NC, discusses the approach to prevention of secondary brain injuries in status epilepticus. The majority of patients with status epilepticus have experienced an acute brain injury and are at risk of experiencing metabolic crisis when seizures occur. Dr Rubinos explains the importance of early diagnosis and intervention of seizures to prevent further brain damage. Scalp EEGs are often utilized but some seizures can only be detected by depth electrodes. However, there is not sufficient data to develop guidelines surrounding their use in status epilepticus. Dr Rubinos also discusses the neuroinflammatory cascade occurring after an acute brain injury or after seizures, which is known to potentiate neuronal hyperexcitability, increasing the likelihood of further seizures. Further research is required to determine reliable biomarkers and effective treatments that can prevent this response and so avoid further brain damage. This interview took place at the American Academy of Neurology (AAN) Annual Meeting 2024 in Denver, CO.

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