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EAN 2023 | Highlights from EAN: rethinking Alzheimer’s targets and AI

Tiago Outeiro, PhD, University Medical Center Gottingen, Gottingen, Germany, highlights key points from the European Academy of Neurology (EAN) 2023 annual meeting, including Prof. Thomas Südhof’s opening lecture on Alzheimer’s disease. The session delved into recent cell biology findings related to Alzheimer’s pathology, suggesting a potential physiological role for amyloid beta peptides in synaptic connectivity. Inhibition of Aβ precursor protein (APP) and inhibition of BACE1 both led to decreased synapse numbers and suppressed synaptic transmission in human neurons, whereas a modest Aβ elevation elevated synapse numbers and synaptic transmission. These findings emphasize the need for a much deeper understanding of the basic disease biology to rationally design new treatments. Prof. Outeiro also discusses the promising developments in utilizing AI for understanding and treating neurological diseases, including its application in deep brain stimulation (DBS). This interview took place at the European Academy of Neurology (EAN) 2023 Congress in Budapest, Hungary.

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