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Francisco Quintana, PhD, Brigham and Women’s Hospital, Boston, MA, talks on the next steps following the identification of different central nervous system (CNS) cell subsets playing a role in the pathogenesis of MS and other neurological diseases. Prof. Quintana explains that new technologies for single-cell analysis of CNS cell interactions in vivo, such as RABID-seq, are enabling us to understand the mechanisms of communication between different cell subsets, which may help to identify new therapeutic targets designed to correct dysregulated cell-cell interactions in disease. This interview took place during the XXV World Congress of Neurology.