Magnus Bäck, MD, PhD, Karolinska Institutet, Stockholm, Sweden, discusses cardiac interventions for stroke prevention, noting the importance of considering different sources of thrombogenicity: cardiac, vascular, and systemic. Cardiac rhythm, atrial mechanics, valve function, and vascular diseases are all important factors that can impact stroke risk, with immunothrombogenicity also being an important consideration. This interview took place at the ESOC 2022 congress in Lyon, France.