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WSC 2025 | The treatment of post-stroke mood disorders: pharmacologic and non-pharmacologic interventions

Maria Epifania V. Collantes, MD, University of the Philippines, Manila, Philippines, discusses the various treatment options for post-stroke mood disorders, including pharmacologic and non-pharmacologic interventions. Dr Collantes highlights the importance of considering the potential side effects of medications and the need to reassess treatment plans over time. This interview took place at the 17th World Stroke Congress (WSC) in Barcelona, Spain.

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Transcript

We have pharmacologic and non-pharmacologic. Pharmacologic, we have all these medications, the antidepressant, anti-anxiety, they’re very effective. But please note that they have side effects also. So you start at a low dose and gradually increase. And once you know that depression doesn’t last for a long time, like after three months, you have to assess, maybe you have to taper the medication...

We have pharmacologic and non-pharmacologic. Pharmacologic, we have all these medications, the antidepressant, anti-anxiety, they’re very effective. But please note that they have side effects also. So you start at a low dose and gradually increase. And once you know that depression doesn’t last for a long time, like after three months, you have to assess, maybe you have to taper the medication. Not only the cost, but the side effects you have to consider. So pharmacologic, there are psychosocial treatments like CBT also, like support groups and all these motivational treatments. We can have also neuromodulation like TMS. This has been proven to have a good effect on post-stroke depression.

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