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AAN 2023 | Results of ocrelizumab in treatment-naïve patients with early relapsing MS

João José Cerqueira, MD, PhD, University of Minho, Braga, Portugal, describes the results of a subgroup analysis from the Phase III OPERA I/OPERA II (NCT01247324/NCT01412333) trials for the treatment of multiple sclerosis (MS) with first-line ocrelizumab (OCR). Selected patients had been diagnosed within two years and had no previous disease-modifying therapies. Patients were treated with OCR or interferon (IFN)-β-1a for a 96-week period. Patients then continued OCR treatment or switched to OCR from IFN for the open-label extension (OLE) of 9 years. Results showed that OCR patients had lower disease activity, disability progression, and relapses. OCR patients also had low levels of malignancies, serious infections, and adverse effects over the 9-year OLE. These results support the use of ocrelizumab as a first-line treatment in patients with early relapsing MS. This interview took place at the American Academy of Neurology Annual Meeting 2023 in Boston, MA.

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JC has received consultancy fees from Biogen, Roche, Novartis, Almirall, Janssen, Bristol-Myers-Squibb, Merck and Zambon; and research grants from Biogen, Roche, Merck and Novartis, as well as the Portuguese Foundation for Science and Technology and Clinical Academic Centre Braga.