In this episode, we explore the relationship between menopause and neurological conditions, and consider how hormonal changes during the menopause transition may influence symptoms, disease management, and brain health. Katarina Rukavina, MD, PhD, Movement Disorders Hospital, Beelitz, Germany, discusses the management of menopause in patients with Parkinson’s disease, followed by Celia Oreja-Guevara, MD, PhD, University Hospital San Carlos, Madrid, Spain, who focuses on multiple sclerosis. Finally, Amber Watts, PhD, University of Kansas, Lawrence, KS, shares insights into the relationship between hormonal changes, cognition, and Alzheimer’s disease.