EAN 2025 | The REFINE study: comorbidity profiles in patients with resistant and refractory migraine
Simona Sacco, MD, University of L’Aquila, L’Aquila, Italy, discusses an analysis of the REFINE study, a multi-centre European study that aims to test the European Headache Federation (EHF) criteria for resistant and refractory migraine. Prof. Sacco reports findings from an analysis that focused on comorbidity profiles in this patient population. This interview took place at the 11th Congress of the European Academy of Neurology (EAN 2025) in Helsinki, Finland.
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Transcript
REFINE study is a multi-centre European study that has the aim to test the EHF criteria for resistant and refractory migraine and to provide better information on characteristics, outcomes, and different features of those patients. So we recruited patients with resistant and refractory migraine according to the EHF definition, but also patients with non-resistant and non-refractory migraine. We looked at the different characteristics...
REFINE study is a multi-centre European study that has the aim to test the EHF criteria for resistant and refractory migraine and to provide better information on characteristics, outcomes, and different features of those patients. So we recruited patients with resistant and refractory migraine according to the EHF definition, but also patients with non-resistant and non-refractory migraine. We looked at the different characteristics. One of the first analyses we published is about the comorbidities. And we showed that some comorbidities are really more common in patients with refractory, especially with the refractory phenotype, and especially psychiatric comorbidities are particularly common in this population. And this is very important because it indirectly tells us that if we want to provide pain relief to those patients with refractory migraine, we need to take care of these comorbidities as well.
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