ESOC 2025 | Targeting the epigenome: epigenetic drugs as a novel approach for stroke treatment
Cristina Gallego-Fabrega, PhD, Sant Pau Research Institute, Barcelona, Spain, discusses the potential of epidrugs, molecules that can alter the epigenome, as a treatment for stroke. Dr Gallego-Fabrega highlights the possibility of using these molecules to reverse epigenetic marks that contribute to disease, noting that a few epigenetic molecules are already approved for cancer treatment, with the hope of finding similar candidates for stroke treatment. This interview took place at the 11th European Stroke Organisation Conference (ESOC) in Helsinki, Finland.
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Transcript
Epidrugs is a new development in the field and it’s the ability to use molecules to alter the epigenome. So these marks I was talking earlier in which we have methylation marks that open or close the ability to transcribe the genome, we can now go and edit those changes and reverse them to a healthier state or to a non-disease state, and those are epidrugs. There’s a few of them that are already approved, especially for cancer treatment, but there are several molecules that are in research right now that are in the process to be evaluated and we hope that with the research that we do we will find good candidates for a stroke to have these epigenetic molecules work on them...
Epidrugs is a new development in the field and it’s the ability to use molecules to alter the epigenome. So these marks I was talking earlier in which we have methylation marks that open or close the ability to transcribe the genome, we can now go and edit those changes and reverse them to a healthier state or to a non-disease state, and those are epidrugs. There’s a few of them that are already approved, especially for cancer treatment, but there are several molecules that are in research right now that are in the process to be evaluated and we hope that with the research that we do we will find good candidates for a stroke to have these epigenetic molecules work on them.
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