AAN 2025 | Redefining acute symptomatic seizure and the importance of patient-related outcomes
Clio Rubinos, MD, University of North Carolina at Chapel Hill, Chapel Hill, NC, discusses efforts to redefine acute symptomatic seizures to include electrographic events identified through electroencephalogram (EEG). Traditionally considered only from a clinical perspective, seizures are now increasingly recognized as a common complication detectable via neurophysiological monitoring. She emphasizes the importance of patient-related outcomes in post-ICU care and the need for comprehensive follow-up to address trauma and support reintegration into society for patients who experience seizures without a diagnosis of epilepsy. This interview took place at the 77th American Academy of Neurology (AAN) Annual Meeting in San Diego, CA.
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Transcript
Something else that is on the horizon and we’re looking into working together is the redefinition of acute symptomatic seizure. It has been a clinical seizure for the longest, but now with more neuroimaging techniques and with neurophysiology monitoring, call it EEG in the ICU and in critically ill patients that are non-ICU, we have recognized that seizures are a very common complication of patients who are critically ill, as I said before...
Something else that is on the horizon and we’re looking into working together is the redefinition of acute symptomatic seizure. It has been a clinical seizure for the longest, but now with more neuroimaging techniques and with neurophysiology monitoring, call it EEG in the ICU and in critically ill patients that are non-ICU, we have recognized that seizures are a very common complication of patients who are critically ill, as I said before. For what, we have to start thinking into redefining acute symptomatic seizures from only the clinical standpoint to also an electrographic standpoint, including those patients as a definition for acute symptomatic seizure. And the last is to discover and discuss patient-related outcomes in these patients. These patients fall into a niche that they do not have epilepsy, but they have suffered a seizure and sometimes these seizures can be quite traumatizing. As in a significant amount of patients, their consciousness is not impaired. So as we follow these patients post-ICU in our clinics, we have to make sure that we are able to address different dimensions to improve quality of life in these patients. For what we’re discovering and looking into getting patient-related outcome surveys and measurements to improve and be comprehensive for patients’ follow-up and for rehabilitation to be able to reinstitute the patients into society.
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Disclosures
Consulting for Azurity and Marinus Pharmaceuticals, Speaker honoraria for Marinus Pharmaceuticals.
